Return to content in this issue

 

Analysis of Lymphocyte and Clinical Profile in Nonmonogenic Common Variable Immunodeficiency Patients With and Without Class Switch Recombination Defect

Tofighi Zavareh F1,2,3,4, Mirshafiey A1,4,5, Yazdani R1,3,6, Keshtkar AA7, Abolhassani H1,8,9, Kiaee F10, Parvaneh N11, Shariat M11, Rezaei N1,3,12, Aghamohammadi A1

1Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2Central Research Laboratory, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Tehran, Iran
4Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
5Livonian Biotech Millennium Ltd, Riga, Latvia
6Department of Neurology, Thomas Jefferson University, Philadelphia, USA
7Department of Health Sciences Education Development, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
8Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
9Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden
10Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
11Department of Pediatrics, Division of Allergy and Clinical Immunology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
12Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

J Investig Allergol Clin Immunol 2023; Vol 33(6) : 474-476
doi: 10.18176/jiaci.0900

Key words: Inborn error of immunity, Primary immunodeficiency, Common variable immunodeficiency (CVID), Unresolved cases, Class switch recombination, Lymphocyte subsets, Clinical phenotype