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Review

Position Statement of the Spanish Society of Allergology and Clinical Immunology on Provocation Tests with Aspirin/Nonsteroidal anti-inflammatory drugs
Izquierdo Domínguez A, Bobolea I, Doña I, Campo P, Segura C, Ortega N, González R, Delgado J, Torres MJ, Dordal MT, and Behalf of the SEAIC Rhinoconjunctivitis Committee
J Investig Allergol Clin Immunol 2020; Vol. 30(5)
doi: 10.18176/jiaci.0449
[summary] [PDF full-Text]

Delayed hypersensitivity reactions caused by drug excipients: A literature review
Caballero ML, Quirce S
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0562
[summary] [PDF full-Text]

Eosinophil Response Against Classical and Emerging Respiratory Viruses: COVID-19
Rodrigo-Muñoz JM, Sastre B, Cañas JA, Gil-Martínez M, Redondo N, del Pozo V
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0624
[summary] [PDF full-Text]

Upper and Lower Airways Functional Examination in Asthma and Respiratory Allergic Deseases. Considerations in the SARS-CoV-2 Post-Pandemic Situation
Olaguibel JM, Alobid I, Alvarez Puebla M, Crespo-Lessmann A, Domínguez Ortega J, García-Rio F, Izquierdo-Domínguez A, Mullol J, Plaza V, Quirce S, Rojas-Lechuga MJ, Valvere-Monge M, Sastre J
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0625
[summary] [PDF full-Text]

Shellfish allergy: unmet needs in diagnosis and treatment
Gelis S, Rueda M, Valero A, Fernández EA, Moran M, Fernández-Caldas E
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0565
[summary] [PDF full-Text]

The Spanish multidisciplinary research network for allergic diseases
Torres MJ, Agundez J, Barber D, Bartra J, Davila I, Escribese MM, Fernandez-Rivas M, Ferrer M, Perez-Inestrosa E, Villalba M, Mayorga C
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0629
[summary] [PDF full-Text]

Treating COVID-19: Review of drug hypersensitivity reactions
Dordal Culla MT, Herrera-Lasso Regás V, Martí-Garrido J, Rodríguez Cumplido D, Vázquez-Revuelta P, Lleonart Bellfill R
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0588
[summary] [PDF full-Text]

Immunoglobulin G4-related Disease: What an Allergist Should Know
Carballo I, González-Quintela A, Sopeña B, Vidal C
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0633
[summary] [PDF full-Text]

Clinical Recommendations for the Management of Biological Treatments in Severe Asthma Patients: A consensus statement
Delgado J, Dávila IJ, Domínguez-Ortega J, on behalf of the Group of Severe Asthma (SEAIC)
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0638
[summary] [PDF full-Text] [Supplemental Materials]

Up-Dosing Antihistamines in Chronic Spontaneous Urticaria: Efficacy and Safety. A Systematic Review of the Literature
Iriarte Sotés P, Armisén M, Usero-Bárcena T, Rodriguez Fernández A, Otero Rivas M, Gonzalez MT, Meijide Calderón A, Veleiro B, Urtigal, the Galician Group of Interest in Urticaria
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0649
[summary] [PDF full-Text]

Original Articles

Molecular allergen profiling of dual mite sensitization in severe allergic rhinitis
González-Pérez R, Pineda F, Poza-Guedes P, Castillo M, Matheu V, Sánchez-Machín I
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0439
[summary] [PDF full-Text]

Quality of Life and characterization of patients with atopic dermatitis in Portugal - QUADEP study
Carvalho D, Aguiar P, Mendes-Bastos P, Palma-Carlos A, Freitas J, Ferrinho P
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0443
[summary] [PDF full-Text]

Paediatric Barcelona Olfactory Test-6 (pBOT-6): Validation of a Combined Odour Identification and Threshold Screening Test in Healthy Spanish Children and Adolescents
Mariño-Sánchez F, Valls-Mateus M, Fragola C, de los Santos G, Aguirre A, Alonso J, Valero J, Santamaría A, Rojas Lechuga MJ, Cobeta I, Alobid I, Mullol J
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0451
[summary] [PDF full-Text]

Farm environment during pregnancy and childhood and polysensitization at the age of 31 - Prospective birth cohort study in Finland
Karvonen AM, Lampi J, Keski Nisula L, Auvinen J, Toppila Salmi S, Järvelin MR, Pekkanen J
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0455
[summary] [PDF full-Text] [Supplemental Materials]

A Comprehensive Prospective Study of Costs Associated to the Evaluation of beta-lactam Allergy
Sobrino García M, Muñoz Bellido FJ, Moreno E, Macías E, Gracia Bara MT, Laffond E, Lázaro Sastre M, Martín García C, de Arriba Méndez S, Campanón Toro MV, Gallardo Higueras A, Dávila I
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0457
[summary] [PDF full-Text] [Supplemental Materials]

Assessing Adherence by Combining the Test of Adherence to Inhalers with Pharmacy Refill Records
Plaza V, Giner J, Curto E, Alonso Ortiz MB, Orue MI, Vega JM, Cosío BG, Group of investigators of the RE-TAI study
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0461
[summary] [PDF full-Text] [Supplemental Materials]

Association between severity of anaphylaxis and coexistence of respiratory diseases: a systematic review and meta-analysis of observational studies
Farias-Aquino E, Tejedor-Alonso MA, Pérez-Fernández E, Moro-Moro M, Rosado-Ingelmo A, Alberti Masgrau N, Pérez-Codesido S, Privitera-Torres M
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0462
[summary] [PDF full-Text]

Factors affecting the success of step-up therapy in patients with moderate-severe asthma: a real-life study
Delgado J, Martinez-Moragón E, Fernández-Sánchez T
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0470
[summary] [PDF full-Text]

SEAIC Specialty Forum: analysis of the current situation of allergology in Spain and its future outlook
Sastre Domínguez J, Valero Santiago A, Montoro Lacomba J, Quirce S, Vidal Pan C, Dávila González I, Olaguibel Rivera JM, Torres Jaén MJ, Rodríguez Vázquez V, Antolin Amerigo D, Ojeda Fernández P, Investigators from a study group
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0473
[summary] [PDF full-Text] [Supplemental Materials]

Anaphylaxis to Vespa velutina nigrithorax: pattern of sensitization for an emerging problem in Western countries
Vidal C, Armisén M, Monsalve R, González-Vidal T, Lojo S, López-Freire S, Méndez P, Rodríguez V, Romero L, Galán A, González-Quintela A
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0474
[summary] [PDF full-Text]

Clinical features and disease management of adult patients with atopic dermatitis receiving care at reference hospitals in Brazil: the ADAPT Study
Arruda LK, Campos Yang A, Aoki V, Fachini Jardim Criado R, Cezar Pires M, Lupi O, Helder Zambaldi Fabricio L, Abreu D, Silvi S
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0478
[summary] [PDF full-Text]

HAE-AS, a specific disease activity scale for hereditary angioedema with C1-inhibitor deficiency
João Forjaz M, Ayala A, Caminoa M, Prior N, Pérez-Fernández E, Caballero T, on behalf of the DV-HAE-QoL study group
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0479
[summary] [PDF full-Text] [Supplemental Materials]

PAGE Study: Summary of a study protocol to estimate the prevalence of severe asthma in Spain using big-data methods
Almonacid Sánchez C, Melero Moreno C, Quirce Gancedo S, Sánchez-Herrero MG, Álvarez Gutiérrez FJ, Bañas Conejero D, Cardona V, Soriano JB
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0483
[summary] [PDF full-Text]

Low expression of ICAM-1 in blood eosinophils in patients with active eosinophilic esophagitis
Pérez-Lucendo I, Gómez Torrijos E, Donado P, Melero R, Feo-Brito F, Urra JM
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0489
[summary] [PDF full-Text] [Supplemental Materials]

Severe cutaneous adverse reactions (SCARs) to drugs in Latin America: RACGRAD study
Rojas Mejía DV, Zwiener RD, Cardona Villa R, Ramírez LF, Silva Espinosa DL, Zanacchi VA, Piraino Sosa P, Ensina LF, Giavina Bianchi P, Coelho Portilho N, Aun MV, Matos Benavides E, Martínez Ruíz DM, Jares E, Serrano Reyes CD
J Investig Allergol Clin Immunol 2020; Vol. 31(4)
doi: 10.18176/jiaci.0497
[summary] [PDF full-Text]

Nailfold Videocapillaroscopic Findings in Bradykinin-Mediated Angioedema
Cesoni Marcelli A, Loffredo S, Petraroli A, Carucci L, Mormile I, Ferrara AL, Spadaro G, Genovese A, Bova M
J Investig Allergol Clin Immunol 2021; Vol. 31(5)
doi: 10.18176/jiaci.0524
[summary] [PDF full-Text]

Endothelial dysfunction and pentraxin-3 in clinically stable adult asthma patients
Pacholczak R, Kuszmiersz P, Iwaniec T, Zaręba L, Zarychta J, Walocha JA, Dropiński J, Bazan-Socha S
J Investig Allergol Clin Immunol 2021; Vol. 31(5)
doi: 10.18176/jiaci.0563
[summary] [PDF full-Text] [Supplemental Materials]

Airborne food and aeroallergens levels in healthcare settings. An unaccounted but potentially relevant source of exposure?
Leal M, Paciência I, Farraia M, Cavaleiro Rufo J, Castro Mendes F, Delgado L, Viegas C, Moreira A
J Investig Allergol Clin Immunol 2021; Vol. 31(5)
doi: 10.18176/jiaci.0623
[summary] [PDF full-Text] [Supplemental Materials]

Direct costs of Acute Rhinosinusitis in Spain - a prospective and observational study (PROSINUS)
Jaume F, Quintó LL, Alobid I, Mullol J
J Investig Allergol Clin Immunol 2021; Vol. 31(6)
doi: 10.18176/jiaci.0525
[summary] [PDF full-Text]

Factors associated with asthma control in 121 preschool children
Leiria-Pinto P, Carreiro-Martins P, Peralta I, Marques J, Finelli E, Alves C, Belo J, Alves M, Papoila AL, Neuparth N
J Investig Allergol Clin Immunol 2021; Vol. 31(6)
doi: 10.18176/jiaci.0630
[summary] [PDF full-Text] [Supplemental Materials]

Anaphylaxis: a decade of a nationwide allergy society registry
Gaspar A, Santos N, Faria E, Câmara R, Rodrigues-Alves R, Carrapatoso I, Gomes E, Pereira AM, Carneiro-Leão L, Morais-Almeida M, Delgado L, Pedro E, Branco-Ferreira M
J Investig Allergol Clin Immunol 2022; Vol. 32(1)
doi: 10.18176/jiaci.0515
[summary] [PDF full-Text]

Molecular Sensitization Profile to Dermatophagoides pteronyssinus Dust Mite in Portugal
Limão R, Spínola Santos A, Araújo L, Cosme J, Inácio F, Tomaz E, Ferrão A, Santos N, Sokolova A, Môrete A, Falcão H, Cunha L, Ferreira A, Bras A, Ribeiro F, Lozoya C, Leiria Pinto P, Prates S, Plácido J, Coimbra A, Taborda-Barata L, Pereira Santos MC, Pereira Barbosa M, Pineda F
J Investig Allergol Clin Immunol 2022; Vol. 32(1)
doi: 10.18176/jiaci.0533
[summary] [PDF full-Text]

Detection of Gibberellin-Regulated Protein (Peamaclein) Sensitization among Italian Cypress Pollen-Sensitized Patients
Asero R, Abbadessa S, Aruanno A, Barilaro G, Barzaghi C, Bignardi D, Bilò MB, Borro M, Bresciani M, Busa M, Buzzulini F, Cavaliere C, Cecchi L, Ciccarelli A, Cortellini G, Cucinelli F, Deleonardi G, Emiliani F, Farsi A, Ferrarini E, Franchini M, Ingrassia A, Lippolis D, Losappio L, Marra AM, Martini M, Masieri S, Mauro M, Mazzolini M, Muratore L, Murzilli F, Nucera E, Pastorello EA, Pinter E, Polillo BR, Pravettoni V, Quercia O, Rizzi A, Russello M, Sacerdoti C, Scala E, Scala G, Scarpa A, Schroeder J, Uasuf GG, Villalta D, Yang B, Mistrello G, Amato S, Lidholm J
J Investig Allergol Clin Immunol 2022; Vol. 32(1)
doi: 10.18176/jiaci.0542
[summary] [PDF full-Text]

MRGPRX2 and Immediate Drug Hypersensitivity: Insights from Cultured Human Mast Cells
Elst J, Sabato V, Faber MA, Bridts CH, Mertens C, Van Houdt M, Van Gasse AL, Hagendorens MM, Van Tendeloo V, Maurer M, Campillo-Davo D, Timmermans JP, Pintelon I, Ebo DG
J Investig Allergol Clin Immunol 2021; Vol. 31(6)
doi: 10.18176/jiaci.0557
[summary] [PDF full-Text] [Supplemental Materials]

Api m 6 and Api m 10 as Major Allergens in Patients with Honeybee Venom Allergy
Vega-Castro A, Rodríguez-Gil D, Martínez-Gomariz M, Gallego R, Peña MI, Palacios R
J Investig Allergol Clin Immunol 2022; Vol. 32(2)
doi: 10.18176/jiaci.0639
[summary] [PDF full-Text] [Supplemental Materials]

Use of Dupilumab for 543 Adult Patients with Moderate-To-Severe Atopic Dermatitis: A Multicenter, Retrospective Study
Nettis E, Ferrucci SM, Ortoncelli M, Pellacani G, Foti C, Di Leo E, Patruno C, Rongioletti F, Argenziano G, Macchia L, Tavecchio S, Napolitano M, Ribero S, Bonzano L, Romita P, Di Bona D, Nisticò SP, Piras V, Calabrese G, Detoraki C, Carbonara M, Fabbrocini G
J Investig Allergol Clin Immunol 2022; Vol. 32(2)
doi: 10.18176/jiaci.0641
[summary] [PDF full-Text]

Clinical and immunologic changes due to subcutaneous immunotherapy with cat and dog extracts using an ultrarush up-dosing phase: a real-life study
Uriarte SA, Grönlund H, Wintersand A, Bronge J, Sastre J
J Investig Allergol Clin Immunol 2022; Vol. 32(2)
doi: 10.18176/jiaci.0656
[summary] [PDF full-Text] [Supplemental Materials]

Practitioner’s Corner

A multicentric study on prevalence of clinical patterns and clinical phenotypes in adult atopic dermatitis
Nettis E, Ortoncelli M, Pellacani G, Foti C, Di Leo E, Patruno C, Rongioletti F, Argenziano G, Ferrucci SM, Macchia L, Napolitano M, Ribero S, Bonzano L, Romita P, Di Bona D, Bennardo L, Piras V, Calabrese G, Tavecchio S, Detoraki C, Carbonara M, Fabbrocini G
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0519
[summary] [PDF full-Text] [Supplemental Materials]

Validation of the Italian version of the Test of Adherence to Inhalers (TAI)
Baiardini I, Paoletti G, Malipiero G, Giua C, Keber E, Canonica GW, Heffler E
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0536
[summary] [PDF full-Text]

Pollen-induced allergic asthma and rhinoconjunctivitis outcomes clearly differ from seasonal exposure to out of the season in real-life conditions: The LANDSCAPE STUDY
Dominguez-Ortega J, Navarro A, Delgado Romero J, Dordal T, Habernau A, Rodríguez M, Mur-Gimeno P, González Gutiérrez ML, Pérez-Francés C, Pascual Miravalles MJ, Colás C, Dávila I, Rodríguez Fernández F, Sánchez Hernández MC, Valero A, The LANDSCAPE STUDY GROUP from the SEAIC
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0544
[summary] [PDF full-Text] [Supplemental Materials]

Allergy to Ailanthus altissima pollen: A local allergen to consider
Martí-Garrido J, Corominas M, Castillo-Fernández M, Belmonte J, Pineda F, Lleonart R
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0577
[summary] [PDF full-Text]

Successful infusion of obinutuzumab by desensitization: A case of anaphylactic shock during desensitization
Kim KW, Chung S, Lee SY, Yoon SS, Kang HR
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0581
[summary] [PDF full-Text]

Allergen Immunotherapy in the era of SARS-CoV-2
Compalati E, Erlewyn-Lajeunesse M, Ali FR, Ojeda Fernández P, Garcia Nuñez I, Frati F, Mistrello G
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0568
[summary] [PDF full-Text]

Quail´s egg anaphylaxis with tolerance to hen´s egg: a work-related case
Ferreira C, Ferreira A, Bartolome B, Lopes I
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0507
[summary] [PDF full-Text]

Negative oral provocation test with porcine pancreatic enzyme plus cofactors despite confirmed α-Gal syndrome
Eberlein B, Mehlich J, Reidenbach K, Pilz C, Hilger C, Darsow U, Brockow K, Biedermann T
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0513
[summary] [PDF full-Text] [Supplemental Materials]

Early-onset inflammatory bowel disease caused by mutations in the X-linked gene IL2RG
Ogawa A, Watanabe T, Natsume T, Okura E, Saito S, Kato S, Nakayama Y, Furukawa S, Yamaguchi T, Kosho T, Uehara T, Kobayashi N, Agematsu K, Nakazawa Y, Shigemura T
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0523
[summary] [PDF full-Text] [Supplemental Materials]

Onset of Schamberg’s disease and resolution of alopecia areata during treatment of atopic dermatitis with dupilumab
Szekely S, Vaccari D, Salmaso R, Belloni-Fortina A, Alaibac M
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0541
[summary] [PDF full-Text]

Rectal Drug formulations´ induced anaphylaxis
Arroabarren E, Aldunate MT, Anda M, Sola L, Tabar AI
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0584
[summary] [PDF full-Text] [Supplemental Materials]

Tranexamic acid plus bemiparin sodium as long-term prophylaxis in a patient with FXII-HAE during pregnancy: a case report
Loli-Ausejo D, Hernández-Martín I, Cabañas R, Entrala A, Gutiérrez–Alvariño M, Martínez-Sánchez N, Caballero T
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0585
[summary] [PDF full-Text]

Omalizumab as a therapeutic option for nasal polyposis in moderate to severe persistent allergic asthma: evidence from a prospective study in a real-world setting
Ruiz-Hornillos J, Rodríguez Jiménez B, Feliu Vila A, Moreno Fernández A, Hernández García MJ, Domínguez-Ortega J, on behalf the ESPLORA group
J Investig Allergol Clin Immunol 2020; Vol. 30(6)
doi: 10.18176/jiaci.0602
[summary] [PDF full-Text] [Supplemental Materials]

Anaphylaxis Due to Senna (Cassia Angustifolia)
Irazábal B, Sánchez de Vicente J, Galán C, Segurola A, Seras Y, García-Lirio E, Martínez Antón MD, Bartolomé B, Jáuregui I
J Investig Allergol Clin Immunol 2021 Vol. 31(1)
doi: 10.18176/jiaci.0608
[summary] [PDF full-Text]

IgE hypersensitivity mediated to lysine clonixinate
Villalón García AL, Pérez Pimiento A, López San Martín MG, Iglesias Cadarso A
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0613
[summary] [PDF full-Text]

Approach to occupational contact dermatitis in an industrialized region of Spain
Carvallo A, Quan P, Goikoetxea MJ, Ferrer M, Penella J, Morales-Palacios MP, Gastaminza G, D’Amelio CM
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0576
[summary] [PDF full-Text]

Serum concentrations of interleukin-6 (IL-6) in the general adult population: possible implications for anti-IL-6 therapy in SARS-Cov-2 infection and IL-6-related diseases
Alende-Castro V, Alonso-Sampedro M, Gude F, Gonzalez-Quintela A
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0601
[summary] [PDF full-Text]

Pertinence of Telehealth in a Rush Conversion to Virtual Allergy Practice during the COVID-19 Outbreak
González-Pérez R, Sánchez-Machín I, Poza-Guedes P, Matheu V, Álava-Cruz C, Mederos Luís E
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0597
[summary] [PDF full-Text]

Anaphylaxis due to perioperative intravenous Lidocaine
Carrión Sari SK, Lezaunr A, Colas Sanz C
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0626
[summary] [PDF full-Text]

Maraviroc, a future treatment of sarcoidosis? An unexpected drug effect
Goehringer F, Tiotiu A, Schvoerer E, Jaussaud R, Hoen B
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0537
[summary] [PDF full-Text] [Supplemental Materials]

Safety and Effectiveness of Dupilumab in Prurigo Nodularis
Romano C
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0550
[summary] [PDF full-Text] [Supplemental Materials]

Shortened up-dosing with 7 injections of subcutaneous allergy immunotherapy (Alutard SQ) is safe and well tolerated
Horn A, Fernández-Rivas M, Wolf H, Ghaussy N, Møller Kruse T, Koutromanou K, Wüstenberg E
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0561
[summary] [PDF full-Text] [Supplemental Materials]

Pilot experience using drug provocation testing for the study of hypersensitivity to chemotherapy and biological agents
Martí-Garrido J, Vázquez-Revuelta P, Lleonart-Bellfill R, Molina-Mata K, Muñoz-Sánchez C, Madrigal-Burgaleta R
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0552
[summary] [PDF full-Text] [Supplemental Materials]

Fixed exanthema after the ingestion of naproxen with tolerance to ibuprofen and dexketoprofen
Reguero Capilla M, De Aramburu Mera T, Ochando Díez-Canseco M, Prados Castaño M
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0518
[summary] [PDF full-Text]

Severe delayed hypersensitivity reaction to abiraterone acetate
Lainez-Nuez A, Crespo J, Noguerado-Mellado B, Tejero-Alcalde M, Tornero P, Rojas-Pérez-Ezquerra P
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0560
[summary] [PDF full-Text]

Relationship between IgE sensitisation to Staphylococcus aureus enterotoxin B, asthma severity and atopy
Barranco P, Palao P, Ruiz I, Domínguez-Ortega J, Vilà-Nadal G, Pola B, Quirce S
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0573
[summary] [PDF full-Text]

Uncommon Signs Associated with Hereditary Angioedema with Normal C1 Inhibitor
Taya J, Veronez CL, Pesquero JB, Bork K, Grumach AS
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0509
[summary] [PDF full-Text] [Supplemental Materials]

Phospholipase A2 Triggers Anaphylaxis to Snake Venom by Repeated Skin Sensitization-A Case Report
Swiontek K, Planchon S, Ollert M, Eyer F, Fischer J, Hilger C
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0545
[summary] [PDF full-Text] [Supplemental Materials]

Unsuccessful Desensitization to Paclitaxel in a Patient with High Basophil Sensitivity
Kopač P, Koren A, Jošt M, Mangaroski D, Lainščak M, Korošec P
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0590
[summary] [PDF full-Text] [Supplemental Materials]

Reverse Takotsubo Cardiomyopathy (rTTC) after a Severe Almond-dependent, Exercise-induced Anaphylaxis
Betancor D, Nuñez-Borque E, Esteban V, Bueno-Díaz C, de las Heras Gozalo M, Pastor-Vargas C, Cuesta-Herranz J
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0598
[summary] [PDF full-Text]

Type 2-driven Inflammation - Atopic Dermatitis, Asthma, and Hypereosinophilia - Successfully Treated with Dupilumab
Benzecry V, Pravettoni V, Segatto G, Marzano AV, Ferrucci S
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0614
[summary] [PDF full-Text] [Supplemental Materials]

Efficacy of therapeutic plasma exchange in a severe immune haemolytic anaemia induced by a carboplatin desensitization procedure
Vilà-Nadal G, Fiandor Román A, Heredia Revuelto R, Hernández-Maraver D, Kerguelen Fuentes AE, Ramírez García E, Cabañas Moreno R
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0634
[summary] [PDF full-Text]

Successful Use of Recombinant Human C1-INH in a Patient with Acquired Angioedema due to C1 Inhibitor Deficiency and an Unusually High Titer of Anti-C1-Inhibitor Autoantibodies
Jesenak M, Brndiarova M, Banovcin P, Varga L, Farkas H
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0635
[summary] [PDF full-Text]

Sustained Unresponsiveness Induced by Oral Immunotherapy Is not a Complete Symptom-Free Condition; a Prospective Case Series
Bemanian MH, Alizadeh F, Nabavi M, Arshi S, Shokri S, Mirsafa MK, Seif F, Fallahpour M
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0636
[summary] [PDF full-Text]

Adult onset sheep’s milk allergy in a patient without cow’s milk allergy
Suzuki K, Futamura K, Hasegawa E, Aoki Y, Nakamura M, Matsunaga K, Yagami A
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0578
[summary] [PDF full-Text] [Supplemental Materials]

Desensitization Protocol to Atezolizumab and Bevacizumab after Severe Anaphylaxis in the Treatment of Lung Adenocarcinoma
Gonzalez-Diaz SN, Villarreal-Gonzalez RV, De Lira-Quezada CE, Rocha-Silva GK, Oyervides-Juarez VM, Vidal-Gutierrez O
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0637
[summary] [PDF full-Text]

Validation of app and phone versions of the Control of Allergic Rhinitis and Asthma Test (CARAT)
Jácome C, Pereira AM, Almeida R, Amaral R, Alves Correia M, Mendes S, Vieira Marques P, Ferreira JA, Lopes I, Gomes J, Vidal C, López Freire S, Méndez Brea P, Arrobas A, Valério M, Chaves Loureiro C, Maia Santos L, Couto M, Araujo L, Todo Bom A, Pedro Azevedo J, Cardoso J, Emiliano M, Gerardo R, Lozoya C, Leiria Pinto P, Castro Neves A, Pinto N, Palhinha A, Teixeira F, Magalhães M, Alves C, Coelho D, Santos N, Menezes F, Gomes R, Cidrais Rodrigues JC, Oliveira G, Carvalho J, Rodrigues Alves R, Moreira AS, Costa A, Abreu C, Silva R, Morête A, Falcão H, Marques ML, Câmara R, Cálix MJ, Bordalo D, Silva D, Vasconcelos MJ, Fernandes RM, Ferreira R, Freitas P, Lopes F, Almeida Fonseca J, INSPIRERS group
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0640
[summary] [PDF full-Text] [Supplemental Materials]

Anaphylaxis after the Epicutaneous Application of Argan Oil
de las Marinas Álvarez MD, Martorell Calatayud C, Castillo Fernández M, Alvariño Martín M, Félix Toledo R, Pineda De La Losa F, Cerdá Mir JC, Martorell Aragonés A
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0596
[summary] [PDF full-Text]

Compassionate Use of a Single Dose of Benralizumab in a Near-Fatal Asthma Exacerbation
Pérez de Llano L, Blanco Cid N, Ortiz Piquer M, Dacal Rivas D
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0609
[summary] [PDF full-Text]

Anaphylaxis Induced By Beer
Navarro L, Lazo C, Pineda F, Labrador-Horrillo M, Roger A, Basagaña M
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0643
[summary] [PDF full-Text]

Anaphylactic Shock to a DEET-Containing Insect Repellent
Giangrande N, García-Menaya JM, Vergara-Prieto E, Pineda De La Losa F, Castillo-Fernández M, Cordobés-Durán C, Marcos-Fernández M, Bobadilla-González P
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0644
[summary] [PDF full-Text] [Supplemental Materials]

Cumulative Pollen Concentration Curves for Pollen Allergy Diagnosis
Hoffmann TM, Travaglini A, Brighetti MA, Acar Şahin A, Arasi S, Bregu B, Caeiro E, Caglayan Sozmen S, Charpin D, Delgado L, Dimou M, Fiorilli M, Fonseca JA, Goksel O, Kalpaklioglu F, Lame B, Mazon A, Mesonjesi E, Nieto A, Öztürk A, Pajno G, Papadopoulos NG, Pellegrini E, Pereira AM, Pereira M, Pinar NM, Pinter E, Priftanji A, Sackesen C, Sfika I, Suarez J, Thibaudon M, Tripodi S, Ugus U, Villella V, Matricardi PM, Dramburg S, @IT.2020 study team
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0646
[summary] [PDF full-Text] [Supplemental Materials]

Kounis Syndrome Due to Urapidil
Herrera-Lasso V, Dordal MT, Alonso G, Camprubí I, Lleonart R
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0645
[summary] [PDF full-Text]

Epithelial Permeability to Ole E 1 Is More Dependent on Functional Bronchial Epithelium-State than on Der P 1-Protease Activity That Acts As Adjuvant to the Bystander Allergen
López-Rodríguez JC, González M, Bogas G, Mayorga C, Villalba M, Batanero E
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0603
[summary] [PDF full-Text] [Supplemental Materials]

Efficacy of Benralizumab and Clinical Course of Igg4 on Eosinophilic Granulomatosis with Polyangiitis
Miyata Y, Inoue H, Homma T, Tanaka A, Sagara H
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0648
[summary] [PDF full-Text]

Profilins and Food Dependent Exercise-Induced Anaphylaxis
Gómez Torrijos E, Gratacós Gómez AR, González Jimenez OM, Joyanes Romo B, Palacios Cañas A, García Rodríguez R
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0650
[summary] [PDF full-Text]

Anaphylaxis to Tranexamic Acid: 2 Cases Confirmed by Drug Provocation Test, What about Skin Tests?
El Hanache H, Verdaguer M, Collin L, Babin M, Favrelière S, Vidal Husser S, Maissiat MH, Hoppe A, Morisset M
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0651
[summary] [PDF full-Text]

Un-Sustained Response to Benralizumab in Eosinophilic Asthma with Previous 3 Year Mepolizumab Administration
Kurosawa M, Shimizu Y, Sutoh Y, Sutoh E
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0652
[summary] [PDF full-Text]

Oxaliplatin Allergy is not Always what it Seems. A Case Report
Farzanegan R, Borrás J, Busquier I, Castelló JV, Torres Gorriz MC, Cervera Aznar R, Enrique E
J Investig Allergol Clin Immunol 2021; Vol. 31(5)
doi: 10.18176/jiaci.0655
[summary] [PDF full-Text]

Seasonal administration of omalizumab in patients with uncontrolled asthma and sensitization to olive pollen
Serrano P, Navas A, Ruiz-León B, Herrero L, Rondón C, Jurado A, Moreno-Aguilar C
J Investig Allergol Clin Immunol 2021; Vol. 31(5)
doi: 10.18176/jiaci.0657
[summary] [PDF full-Text] [Supplemental Materials]

Icatibant in Severe Acute Respiratory Syndrome Coronavirus 2: a case description
Pecori D, Della Siega P, Sozio E, Barbano E, Mazzoran L, Zanichelli A, Sbrana F, Federico I, Bassi F, Fabris M, Vendramin I, Sbrojavacca R, Tascini C
J Investig Allergol Clin Immunol 2021; Vol. 31(5)
doi: 10.18176/jiaci.0659
[summary] [PDF full-Text] [Supplemental Materials]

Letters to the Editor

The rediscovery of hydroxychloroquine in allergic diseases in the COVID-19 era
Bonzano L, Cassone G, Tarallo L, Pellacani G
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0575
[summary] [PDF full-Text]

Benralizumab in real life
Miralles López JC, Escudero Pastor AI, Carbonell Martínez A, Navarro Garrido C, Bonilla Pacheco Y, Petrik Petrik Y
J Investig Allergol Clin Immunol 2021; Vol. 31(1)
doi: 10.18176/jiaci.0599
[summary] [PDF full-Text]

COVID-19 & Allergy: Allergists Workload During the Pandemic
Fernández-de-Alba I, Brigido C, García-Gutierrez I, Antolín-Amérigo D, Sánchez-García S
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0632
[summary] [PDF full-Text] [Supplemental Materials]

Severe Asthma Units Accredited by Spanish Society of Allergology and Clinical Immunology (SEAIC). Experience and Future
Delgado Romero J, Miralles López JC, Álvarez Puebla M, Fernández Ibáñez E, Habernau Mena A
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0618
[summary] [PDF full-Text]

Descriptive study of job opportunities in the allergy field
Posadas Miranda T, Rial Prado MJ, Meiji de Calderón A, Fernández de Alba Porcel I, Zambrano Ibarra G, on behalf of the commission of young allergists and MIR (CAJMIR) of Spanish Society of Allergology and Immunology (SEAIC)
J Investig Allergol Clin Immunol 2021; Vol. 31(2)
doi: 10.18176/jiaci.0631
[summary] [PDF full-Text]

Eosinophil Count in Induced Sputum Could Be More Sensitive Than In Peripheral Blood to Phenotype Patients with Severe Eosinophilic Asthma
Caballero ML, Dominguez-Ortega J, Nin-Valencia AR, Sánchez-Ocando H, Barranco P
J Investig Allergol Clin Immunol 2021; Vol. 31(4)
doi: 10.18176/jiaci.0647
[summary] [PDF full-Text]

JAK inhibition as a therapeutic strategy for IgG4-RD
Khan S, Gordins P, Durairaj S
J Investig Allergol Clin Immunol 2021; Vol. 31(3)
doi: 10.18176/jiaci.0654
[summary] [PDF full-Text]