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Regulatory B Cells and Allergy: Uncovering the Link

Mota I1, Martins C2, Borrego LM1,2

1Immunoallergy Department, CUF Descobertas Hospital, Lisbon, Portugal
2CEDOC, Chronic Diseases Research Center, Immunology, NOVA Medical School|FCM, Universidade Nova de Lisboa, Lisbon, Portugal

J Investig Allergol Clin Immunol 2017; Vol 27(4) : 204-212
doi: 10.18176/jiaci.0157

Regulatory B (Breg) cells are recognized as immunosuppressive cells. During the last few years, several subsets of Breg cells with different phenotypes and suppressive mechanisms have been described in the literature. We review the role of Breg cells in allergy based on an extensive literature search in PubMed.
We describe the types and mechanisms of action of B cells and their role in the pathogenesis of several allergic diseases (allergic asthma, allergic rhinitis, food allergy, contact hypersensitivity, and anaphylaxis).

Key words: Regulatory B cells, Allergy, Allergic disease, Allergen tolerance, B10, Br1, Asthma, Food allergy, Hymenoptera venom allergy, Pregnancy